Zak: I don’t know, I’ve only ever been on the gel and Adrian has only ever been on injections. The major difference is that you will be putting hormones into your body every day instead of every week (or every other week), which means that your levels will likely be more stable on the gel. However, you may or may not notice any differences because of this. I’ve heard of several people switching from injections to the gel once they are further along in transition but none have mentioned feeling all that much different. You might want to ask your doctor for more details about this.